Umbilical cord blood metal levels in newborns

Umbilical cord blood metal levels in newborns


New findings from a team of Marshall University Joan C. Edwards School of Medicine researchers reveal urban and rural differences in prenatal exposure to essential and toxic elements.

The team’s finding were published in November in The Journal of Toxicology and Environmental Health.

The research team of Jesse N. Cottrell, D’Andrea Thomas, Brenda Mitchell, Jason Childress, Diane Dawley, Lawrence Harbrecht, David Jude and Monica Valentovic, conducted a comparative, cross-sectional study on 172 pregnant women – 79 who were considered rural and 93 considered urban as determined by US Census Rural-Urban Commuting Area Codes. Umbilical cord blood was collected at the time of delivery and analysed for 20 inorganic elements.

The study found significant differences between urban and rural samples for two elements. Copper and molybdenum were higher in urban samples. No marked differences between groups occurred for arsenic, barium, cadmium, calcium, cobalt, lead, lithium, magnesium, manganese, mercury, selenium, strontium or zinc. All samples were devoid of platinum, silver, thallium or uranium. Self-reported tobacco use was 25 per cent and 26.9 per cent in the rural and urban groups respectively. Nicotine product exposure was confirmed by measuring cotinine, a stable metabolite of nicotine. Nicotine usage was associated with higher levels of lead, manganese and copper levels compared to non-smokers.

“The feotus and placenta are particularly vulnerable to toxins due to the immaturity of the blood-brain barrier and diminished biotransformation enzymatic activity,” said Valentovic, the study’s principal investigator. “Excess or inadequate levels of inorganic ions may induce significant acute and long-term irreversible dysfunction in humans. Further analysis is needed to determine if there is a link between neonatal outcomes and prenatal exposure to these elements.”

Source: Marshall University

Reference: Jesse N. Cottrell, D’Andrea S. Thomas, Brenda L. Mitchell, Jason E. Childress, Diane M. Dawley, Lawrence E. Harbrecht, David A. Jude, Monica A. Valentovic. Rural and urban differences in prenatal exposure to essential and toxic elementsJournal of Toxicology and Environmental Health, Part A, 2018; 81 (23): 1214 DOI: 10.1080/15287394.2018.1547890

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